Lack of association between circulating levels of oxidized LDL/β2-glycoprotein I complexes and leukocyte ABCA1 gene expression
نویسندگان
چکیده
منابع مشابه
Lack of Association between Somatotropin Receptor Gene Polymorphism and Birth Weight of Iranian Indigenous Sistani Cattle
The objective of the present study was to determine polymorphism within the promoter region of somatotropin receptor genes in indigenous Sistani cattle (Bos indicus) and associations between this polymorphism and breeding value of birth weight. The pedigree structure was included by considering 1173 animals with 600 progeny birth weight data obtained from a Zhark breeding station in Sistan and ...
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چکیده: سرطان پستان دومین عامل مرگ مرتبط با سرطان در خانم ها است. از آنجا که سرطان پستان یک تومور وابسته به هورمون است، می تواند توسط وضعیت هورمون های استروئیدی شامل استروژن و پروژسترون تنظیم شود. استروژن نقش مهمی در توسعه و پیشرفت سرطان پستان ایفا می کند و تاثیر خود را روی بیان ژن های هدف از طریق گیرنده های استروژن اعمال می کند. اما گروه دیگری از گیرنده های هسته ای به نام گیرنده های مرتبط به ا...
15 صفحه اولCirculating oxidized LDL forms complexes with beta2-glycoprotein I: implication as an atherogenic autoantigen.
Beta2-glycoprotein I (beta2-GPI) is a major antigen for antiphospholipid antibodies (Abs, aPL) present in patients with antiphospholipid syndrome (APS). We recently reported (J. Lipid Res., 42: 697, 2001; J. Lipid Res., 43: 1486, 2002) that beta2-GPI specifically binds to Cu2+-oxidized LDL (oxLDL) and that the beta2-GPI ligands are omega-carboxylated 7-ketocholesteryl esters. In the present stu...
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Objective(s): Coronary artery disease (CAD) which may lead to myocardial infarction (MI) is a complex one. Great effort has been devoted to identification of genes that increase susceptibility to CAD or provide protection. A 21-bp deletion in the MEF2A gene, which encodes a member of the myocyte enhancer factor 2 family of transcription factors, has been reported in patients of a single pedigr...
متن کاملLack of Association between Promoter Gene Polymorphism (-318 C/T) and Multiple
Multiple sclerosis (MS), a chronic inflammatory demyelinating disease of the central nervous system is believed to have a T cell-mediated autoimmune etiology. The cytotoxic T lymphocyte antigen 4 (CTLA-4) gene is a strong candidate for the involvement in autoimmune diseases. To examine the genetic association of the CTLA-4 gene locus with MS, in a case-control design, we analyzed (-318 C/T) sin...
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ژورنال
عنوان ژورنال: Annals of Clinical Biochemistry: International Journal of Laboratory Medicine
سال: 2011
ISSN: 0004-5632,1758-1001
DOI: 10.1258/acb.2011.010194